Steve Dixon:
CLASS OF 1972
Marathon High SchoolClass of 1972
Marathon, FL
Big Bear High SchoolClass of 1972
Big bear lake, CA
Big Bear Elementary SchoolClass of 1965
Big bear lake, CA
Steve's Story
Life
Hi there!
After attending Marathon High in the Florida Keys, I moved back to Big Bear Lake, CA. I joined the Navy in 1973, and have lived in San Diego County since. In the Navy, I worked as a Hospital Corpsman in the intensive care units of the naval hospital in San Diego.
My training as a hospital corpsman allowed me to obtain an LVN license after my honorable discharge. I worked as an LVN in hospitals and private homes while I attended college.
In 1984, I graduated from UCSD. I have worked at several biotech companies. For over ten years, I have worked as an Analytical Chemist. At Ligand Pharmaceuticals, I helped with the development of two drugs in oral and topical formulations. These drugs are currently on the market and are being used to treat cancer patients.
I married Patty in 1984, and we have three children: 23, 21, and 17 years old. Patty was born in Sonora, Mexico. We usually converse in Spanish, and my children are bilingual.
I enjoy hiking, camping, backpacking, and traveling. I have backpacked the entire John Muir Trail (except for a small portion in Yosemite). My best memory was arriving at the summit of Mt. Whitney. At 14,500 feet elevation, Whitney is the highest peak in the lower 48 states.
College
Certificate in Recombinant DNA Technology
San Diego State University, San Diego, CA
Bachelor of Arts Degree
University of California, San Diego
Major: Biology with a specialization in Animal Physiology
Minor: Music Literature
Workplace
Natural Alternatives International, San Marcos, CA (3/04 to 10/05)
Research Chemist:
Develop and validate assay methods using various analytical instruments. Write Standard Operating Procedures for these newly developed methods for transfer to the Quality Control Department. Perform analyses of raw materials for the Department of Research and Development.
· Optimized and validated two methods for the determination of antioxidative capacity of water- and lipid-soluble compounds in raw materials using a Photochem analyzer. Wrote Standard Operating Procedures and validation summaries for these methods. Determined the antioxidative capacity of botanical extract powders, nutritional supplements, and other materials.
VitaGen Incorporated, La Jolla, CA (12/00 to 6/02)
Research Associate III:
Provided analytical support and scientific expertise to the Engineering and Biochemistry groups. Developed methods and quantitated compounds, metabolites, and proteins in a variety of matrices.
· Developed a robust method for the analysis of Lidocaine and its metabolite, MEGX, in plasma or cell media to support the Engineering groupÂs studies of the metabolic efficiency of hepatocytes growing in hollow-fiber cartridges.
· Developed methods for determining protein permeability of hollow-fiber cartridges. Protein solutions were circulated through the cartridges and time samples were analyzed for protein levels using size-exclusion HPLC. Rate and extent of protein diffusion were then calculated.
· Optimized and implemented methods for the quantitation of testosterone, acetaminophen, Lidocaine, Diazepam, and their respective metabolites to support the Biochemistry groupÂs studies of cytochrome P450 enzymatic activities of hepatocytes in cell culture.
· Assured laboratory safety and OSHA compliance as the Safety Officer at VitaGen's La Jolla facility. Implemented company-sponsored programs that provide lab employees with prescription safety glasses and Hepatitis B vaccination. Ordered safety equipment, organized training, and maintained records and documents.
Corvas International, San Diego, CA (5/95 to 8/00)
Associate Scientist I-II:
Worked in the An...Expand for more
alytical Chemistry Group. Developed methods and quantitated drug candidates in biological matrices. Performed solid phase extraction or protein precipitation, followed by HPLC with fluorescent or mass spectrographic detection. Tabulated data and submitted reports using MS Excel and MS Word.
· Developed and validated a sensitive assay for the simultaneous analysis of a drug candidate and its metabolite in human urine. Used this assay in the quantitation of clinical samples. Processed data (tabulation and ANOVA statistical analysis) and submitted reports. The data was published in the Journal of Chromatography A.
· Developed methods for the analysis of a difficult class of compounds in plasma. When the standard methods of analysis were employed, poor extraction recoveries and nonlinear standard curves were obtained. Tested and optimized method parameters, including extraction conditions, HPLC mobile phase, post-column reaction conditions, and detection method. The optimized methods resulted in excellent extraction recoveries and standard curves with good linearity. Presented this work in poster form at a company-wide conference.
· Developed methods for the analysis of multiple (typically ten) compounds in plasma. Wrote macros in Excel to facilitate the transfer of the resulting large volumes of data into tables, thereby increasing productivity, eliminating transcription errors, and saving considerable time.
· Received cash bonuses for each of the three achievements listed above.
· Developed an ultrafiltration method for determining plasma protein binding. Used this method to determine binding of over 20 experimental compounds in rat, dog, and human plasma.
(Continued under military profile tab)
Military
(Continued from workplace tab)
Ligand Pharmaceuticals, San Diego, CA (10/89 to 2/95)
Senior Research Associate: (9/92 to 2/95)
Worked in the Department of Pharmacokinetics and Toxicology. Quantitated retinoid analogues in biological matrices (urine, plasma, and feces) under GLP requirements. Performed protein precipitation, followed by HPLC with UV detection. Tabulated data and submitted reports using MS Excel and MS Word. Performed radiometric analyses using liquid scintillation counting with an excellent understanding of the theory involved. Developed and validated methods.
· Performed the pharmacokinetic analyses leading to four IND applications, including sample preparation, radiometric and UV-HPLC quantitation, and data processing. Created all the tables and graphs used in the department reports for these IND applications.
· Developed an ultrafiltration method with radiometric detection for determining plasma protein binding. Used this method for determining plasma protein binding for two retinoids in three species.
Senior Research Assistant II: (10/89 to 9/92)
Produced high quality plasmid DNA using large-scale preps to supply the increasing demand in this rapidly growing company. This DNA was used in the companyÂs proprietary co-transfection screening assays.
· Improved existing methods thereby increasing the weekly yield of DNA from a few milligrams to as much as 72 milligrams.
· Provided more than 500 plasmids having a total mass of over 2.1 grams in this 3-year period.
Synbiotics Incorporated, San Diego, CA (11/88 to 8/89)
Associate Scientist I:
Screened monoclonal antibodies using radioreceptor assays. Positives were column purified and tested in vivo. Performed partially-purified plasma membrane preps, I-125 iodinations, and hypophysectomy of rats. As Assistant Radiation Safety Officer, responsibilities included monitoring company-wide usage of radioisotopes.
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